The growth-survival trade-off is hard-wired in the Lactococcus lactis gene regulation network.

Environ Microbiol Rep

TiFN, Agro Business Park 82, Wageningen, 6708 PW, The Netherlands.

Published: August 2022

Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non-spore-forming Lactococcus lactis KF147 progressively activates the expression of stress-associated functions in response to the declining growth rate elicited by prolonged retentostat cultivation, which coincides with up to 10 -fold increased stress tolerance. Our findings provide a quantified view of the transcription and stress-tolerance adaptations underlying the growth-survival trade-off in L. lactis, and exemplify the hard-wiring of this trade-off in the lactococcal gene regulation network.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544163PMC
http://dx.doi.org/10.1111/1758-2229.13073DOI Listing

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