Prevalance of Microalbuminuria in Non Diabetic Ischemic Heart Disease Patients.

Unlabelled: Gadag Ischemic heart disease (IHD) is atherosclerotic narrowing of coronary arteries that is often asymptomatic early in the course of the disease but may lead to stable or unstable angina, and/or myocardial infarction with the progressive thickening or plaque rupture of the wall of the coronary arteries. Ischemic heart disease has now become one of the leading causes of death worldwide, accounting for more than 7.3 million deaths in 2008 alone. Microalbuminuria is a widely recognized, strong and independent risk marker of cardiovascular disease among individuals with diabetes, which as a marker of IHD in nondiabetics is currently under international debate.

Material: In a cross-sectional study, 100 clinically diagnosed IHD patients were recruited, by using standard questionnaire demographic data, drug usage, disease history and physical examination were noted. Absence of diabetes mellitus was documented by no history of diabetes mellitus and evaluating serum blood glucose and HbA1c. Presence of microalbuminuria was confirmed by microalbumin quantitative estimation.

Observation: The mean age of the patients was 54.23 ± 14.44 years, ranging between 27 to 82 years. There was male predominance (84%) compared to females (16%). 51% of patients were smokers while 25% were alcoholics. Hypertension was reported to be the most prevalent comorbidity followed by Hyperhomocysteinemia and Hypothyroidism. The presence of microalbuminuria was found among 43 out of total 100 patients. Therefore, the incidence of microalbuminuria was 43%. There was no significant difference in the means of BSL, HbA1c and creatinine noted among the groups based on presence or absence of microalbuminuria. A significant positive association between presence of comorbidities and abnormal triglyceride level with presence of microalbuminuria was reported, while smoking status, alcoholic status and abnormal serum cholesterol level were not associated significantly with presence of microalbuminuria.

Conclusion: In the present study higher prevalence of microalbuminuria was reported among non-diabetic IHD patients, which might be caused due to presence of hypertension. Therefore, the present study recommends estimating urine microalbumin to identify high-risk individuals for IHD, for primary prevention of it.