AI Article Synopsis
- Diabetes mellitus (DM) is linked to serious kidney complications, with chronic inflammation playing a key role in type 2 diabetes progression, potentially detectable through simple inflammatory markers.* -
- A study involving 90 type 2 diabetic patients tested the relationship between neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) and the presence of microalbuminuria.* -
- Results indicated a significant correlation, especially with NLR showing promise in predicting microalbuminuria, suggesting these markers are cost-effective tools for early kidney disease detection in diabetic patients.*
Article Abstract
Unlabelled: Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. DM is one of the most common causes of chronic kidney disease CKD, end-stage renal disease (ESRD). Chronic inflammation has an important role in the development and progression of type 2 diabetes through immunologic inflammatory mechanisms. Simple new inexpensive inflammatory markers may contribute to the detection of microalbuminuria. Our aim is to study the correlation of neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) with microalbuminuria in type 2 diabetic patients.
Material: This was a single-center, cross-sectional study and was conducted from November 2020 to October 2021 in a tertiary care center in Eastern Odisha. Study subjects were patients with type 2 Diabetes Mellitus. A total of 90 patients with type 2 diabetes mellitus were classified into gender- and BMI-matched three groups according to hemoglobin A1c and microalbuminuria: Group A: 30 patients with controlled diabetes, without microalbuminuria Group B: 30 patients with uncontrolled diabetes, without microalbuminuria, and Group C: 30 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR and RDW between the study groups were examined and compared.
Observation: A significant difference in NLR was found between Group C and groups A and B (P <.001, P =.008, respectively). A statistically significant difference in RDW was found between groups B and C (P =.015). Receiver operating characteristic curve analysis of inflammatory markers and microalbuminuria prediction showed an area under the curve (AUC) of 0.69 for NLR and 0.61 for RDW.
Conclusion: NLR and RDW have a positive correlation with urine ACR and have PPV for microalbuminuria in diabetic patients. NLR and RDW are cheap and inexpensive methods for detecting nephropathy early in diabetes patients.
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