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Mechanical forces instruct division plane orientation of cambium stem cells during radial growth in Arabidopsis thaliana.
Curr Biol
December 2024
Technical University of Munich, TUM School of Natural Sciences, Department of Bioscience, Center for Protein Assemblies (CPA), 85748 Garching b. München, Munich, Germany. Electronic address:
Robust regulation of cell division is central to the formation of complex multi-cellular organisms and is a hallmark of stem cell activity. In plants, due to the absence of cell migration, the correct placement of newly produced cell walls during cell division is of eminent importance for generating functional tissues and organs. In particular, during the radial growth of plant shoots and roots, precise regulation and organization of cell divisions in the cambium are essential to produce adjacent xylem and phloem tissues in a strictly bidirectional manner.
View Article and Find Full Text PDFAI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.
PLoS Comput Biol
November 2024
Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany.
Understanding how multicellular organisms reliably orchestrate cell-fate decisions is a central challenge in developmental biology, particularly in early mammalian development, where tissue-level differentiation arises from seemingly cell-autonomous mechanisms. In this study, we present a multi-scale, spatial-stochastic simulation framework for mouse embryogenesis, focusing on inner cell mass (ICM) differentiation into epiblast (EPI) and primitive endoderm (PRE) at the blastocyst stage. Our framework models key regulatory and tissue-scale interactions in a biophysically realistic fashion, capturing the inherent stochasticity of intracellular gene expression and intercellular signaling, while efficiently simulating these processes by advancing event-driven simulation techniques.
View Article and Find Full Text PDFAuthor Correction: Real-time conversion of tissue-scale mechanical forces into an interdigitated growth pattern.
Nat Plants
July 2021
Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, USA.
Rab7 is required for mesoderm patterning and gastrulation in Xenopus.
Biol Open
July 2021
Department of Zoology, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior. Intracellularly, the endolysosomal system emerges as an important regulator at different levels, but in vivo studies are rare.
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