This report describes a method for the deoxyfluorination of alcohols with KF as the fluorine source via in situ generation of highly active CFSOF. Diverse functionalities, including halogen, nitro, ketone, ester, alkene, and alkyne, are well tolerated. Mild conditions, a short reaction time, and a wide substrate scope make this method an excellent choice for the construction of C-F bonds.
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Article Synopsis
- A novel method for deoxyfluorination of various alcohols using a nontrigonal phosphorus triamide allows for the activation of alcohols without a base.
- This process incorporates an organic soluble fluoride donor and a triarylborane fluoride shuttling catalyst to facilitate the reaction.
- The study also shows that this method expands on current deoxyfluorination techniques, allowing for the creation of homochiral secondary and tertiary alkylfluorides through stereoinversion of the original alcohol.
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