AI Article Synopsis
- - The shape and structure of epithelial cells are crucial for their proper functioning, but how these shapes are formed isn't fully understood.
- - The study by Marivin et al. identifies DAPLE as a key protein that connects polarity complexes and the actomyosin network at the points where cells touch each other (apical junctions).
- - DAPLE helps maintain the right cell shape and function by bringing in another protein (CD2P) and activating a signaling pathway (Gαβγ-mediated RhoA signaling).
Article Abstract
Epithelial cell morphology is essential for cellular homeostasis, but the mechanisms by which cell shape is established remain unclear. In this study, Marivin et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111002) identify DAPLE as a linker between polarity complexes and the actomyosin network at apical junctions. By recruiting CD2P and activating Gαβγ-mediated RhoA signaling, DAPLE ensures proper cell shape and function.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195049 | PMC |
| http://dx.doi.org/10.1083/jcb.202203035 | DOI Listing |
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