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DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model.
Vaccines (Basel)
July 2022
Neomatrix, 00128 Rome, Italy.
The COVID-19 pandemic is entering a new era with the approval of many SARS-CoV-2 vaccines. In spite of the restoration of an almost normal way of life thanks to the immune protection elicited by these innovative vaccines, we are still facing high viral circulation, with a significant number of deaths. To further explore alternative vaccination platforms, we developed COVID-Vax-a genetic vaccine based on plasmid DNA encoding the RBD domain of the SARS-CoV-2 spike protein.
View Article and Find Full Text PDFMolnupiravir in COVID-19: A Scoping Review.
Curr Drug Res Rev
October 2022
Department of Pharmacology, All India Institute of Medical Sciences, Bhopal, India.
Background: COVID-19, first detected in Wuhan, China, has evolved into a lifethreatening pandemic spread across six continents, with the global case count being more than 243 million, and mortality over 4.95 million, along with causing significant morbidity. It has initiated an era of research on repurposed drugs such as hydroxychloroquine, lopinavir/ritonavir, corticosteroids, remedesivir, ivermectin, alongside selective antivirals to treat or prevent COVID- 19.
View Article and Find Full Text PDFThe Ferret Era of Experimental Lung Transplantation Is Upon Us.
Transplantation
October 2022
Department of Surgery, University of Maryland, Baltimore, MD.
Current State of Knowledge about Role of Pets in Zoonotic Transmission of SARS-CoV-2.
Viruses
June 2021
Department of Microbiology, Wrocław Medical University, St. T. Chałubińskiego 4, 50-376 Wrocław, Poland.
Pets play a crucial role in the development of human feelings, social life, and care. However, in the era of the prevailing global pandemic of COVID-19 disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many questions addressing the routes of the virus spread and transmission to humans are dramatically emerging. Although cases of SARS-CoV-2 infection have been found in pets including dogs, cats, and ferrets, to date there is no strong evidence for pet-to-human transmission or sustained pet-to-pet transmission of SARS-CoV-2.
View Article and Find Full Text PDFControl of Brain State Transitions with a Photoswitchable Muscarinic Agonist.
Adv Sci (Weinh)
July 2021
Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology, Barcelona, 08028, Spain.
The ability to control neural activity is essential for research not only in basic neuroscience, as spatiotemporal control of activity is a fundamental experimental tool, but also in clinical neurology for therapeutic brain interventions. Transcranial-magnetic, ultrasound, and alternating/direct current (AC/DC) stimulation are some available means of spatiotemporal controlled neuromodulation. There is also light-mediated control, such as optogenetics, which has revolutionized neuroscience research, yet its clinical translation is hampered by the need for gene manipulation.
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