AI Article Synopsis
- A new method is introduced that combines two reactions (SAr and Boulton-Katritzky rearrangement) using a base to create functionalized [1,2,4]triazolo[1,5-]pyridines.
- This process utilizes starting materials like 1,2,4-oxadiazol-3-amines or 3-aminoisoxazoles reacting with 2-fluoropyridines.
- The approach is described as simple and direct, making it an accessible option for synthesis in organic chemistry.
Article Abstract
A base-promoted tandem SAr/Boulton-Katritzky rearrangement is developed. It offers a simple and straightforward method for the formation of functionalized [1,2,4]triazolo[1,5-]pyridines from 1,2,4-oxadiazol-3-amines or 3-aminoisoxazoles with 2-fluoropyridines.
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| http://dx.doi.org/10.1021/acs.orglett.2c00863 | DOI Listing |
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