AI Article Synopsis
- Retroperitoneal fibrosis (RPF) is a rare condition characterized by the development of fibrous tissue in the retroperitoneum, with two main subtypes: vascular and urorenal.
- From 2005 to 2021, a study found 27 patients with the vascular subtype and 11 with the urorenal subtype, highlighting demographic differences.
- The urorenal subtype showed significantly worse kidney function and higher cholesterol levels, while the vascular subtype had a higher prevalence of cardiovascular risk factors like hypertension and diabetes, indicating diagnostic and therapeutic challenges due to symptom diversity.
Article Abstract
Introduction: Retroperitoneal fibrosis (RPF) is a rare disease associated with the formation of hard inflammatory and fibrous tissue in the retroperitoneum. Taking into consideration the fact that RPF is a rare disease with different subtypes, we compared the basal clinical and biochemical characteristics of the vascular and urorenal subtypes.
Patients And Methods: From January 2005 until December 2021, 27 patients were identified as vascular subtype (18 males) and 11 as urorenal subtype (9 males).
Results: Patients with a primary urorenal origin had significantly worse kidney function as reflected by serum creatinine and eGFR (both < 0.001); they also had higher serum cholesterol ( < 0.01). Hypertension, diabetes, hyperlipidemia and nicotinism were significantly more prevalent in vascular subtype (all < 0.001).
Conclusion: Vascular subtype is more prevalent in our study with more cardiovascular risk factor present. Due to the diversity of symptoms, diagnosis of RPF becomes a challenge for specialists as well as therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037163 | PMC |
| http://dx.doi.org/10.1080/0886022X.2022.2064303 | DOI Listing |
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