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Deep Learning-Based Multi-View Projection Synthesis Approach for Improving the Quality of Sparse-View CBCT in Image-Guided Radiotherapy.
J Imaging Inform Med
January 2025
School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, China.
While radiation hazards induced by cone-beam computed tomography (CBCT) in image-guided radiotherapy (IGRT) can be reduced by sparse-view sampling, the image quality is inevitably degraded. We propose a deep learning-based multi-view projection synthesis (DLMPS) approach to improve the quality of sparse-view low-dose CBCT images. In the proposed DLMPS approach, linear interpolation was first applied to sparse-view projections and the projections were rearranged into sinograms; these sinograms were processed with a sinogram restoration model and then rearranged back into projections.
View Article and Find Full Text PDFNew insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis.
Front Med (Lausanne)
January 2025
Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Łódź, Łódź, Poland.
Introduction: Inflammasomes NLRP1 (NLR family pyrin domain containing 1) and NLRP3 are pivotal regulators of the innate immune response, activated by a spectrum of endogenous and exogenous stressors, including ultraviolet radiation (UVR). The precise molecular mechanisms underlying the activation of these inflammasomes remain unclear. Furthermore, the involvement of interleukin-33 (IL-33) in UVR-induced skin carcinogenesis is not well defined.
View Article and Find Full Text PDFCMTM4 promotes the motility of colon cancer cells under radiation and is associated with an unfavorable neoadjuvant chemoradiotherapy response and patient survival in rectal cancer.
Oncol Lett
March 2025
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC). Pathological complete regression is closely linked to disease outcomes. However, biomarkers predicting nCRT response and patient survival are lacking for LARC.
View Article and Find Full Text PDFTargeting SRSF1 improves cancer immunotherapy by dually acting on CD8T and tumor cells.
Signal Transduct Target Ther
January 2025
Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Serine arginine-rich splicing factor 1 (SRSF1) is a key oncogenic splicing factor in various cancers, promoting abnormal gene expression through post-translational regulation. Although the protumoral function of SRSF1 is well-established, the effects of inhibiting tumor-intrinsic SRSF1 on the tumor microenvironment and its impact on CD8 T cell-mediated antitumor immunity remain unclear. Our findings indicate that depleting SRSF1 in CD8 T cells improve antitumor immune function, glycolytic metabolism, and the efficacy of adoptive T cell therapy.
View Article and Find Full Text PDFInstantaneous self-recovery and ultra-low detection limit hydrogel electronic sensor for temporomandibular disorders intelligent diagnosis.
Nat Commun
January 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Temporomandibular disorders (TMD) intelligent diagnosis promises to elevate clinical efficiency and facilitate timely TMD management for patients. However, development of TMD intelligent diagnostic tools with high accuracy and sensitivity presents challenges, particularly in sensing minute deformations and ensuring rapid self-recovery. Here we report a biocompatible hydrogel electronic sensor with instantaneous self-recovery (within 2.
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