AI Article Synopsis
- Kidney stone disease (KSD) has a high recurrence rate (6.1% to 66.9%), and this study aims to identify risk factors impacting its recurrence.
- Researchers conducted a meta-analysis of 53 studies, resulting in data from over 488,000 patients, to evaluate various risk factors associated with KSD recurrence.
- The analysis found 12 significant risk factors, including younger age, higher BMI, family history of kidney stones, and personal history of the disease, which can help in developing prediction models and prevention strategies against KSD recurrence.
Article Abstract
Background: Kidney stone disease (KSD) is a common illness that causes an economic burden globally. It is easy for patients to relapse once they have suffered from this disease. The reported recurrence rate of KSD ranged from 6.1% to 66.9%. We performed this meta-analysis to identify various potential risk factors for the recurrence of KSD.
Methods: The PubMed, Embase and Web of Science databases were searched using suitable keywords from inception to Mar 2022. A total of 2,663 records were collected initially. After screening the literature according to the inclusion and exclusion criteria, 53 articles (40 retrospective studies; 13 prospective studies) including 488,130 patients were enrolled. The study protocol was registered with PROSPERO (No. CRD42020171771).
Results: The pooled results indicated that 12 risk factors including younger age (n = 18), higher BMI (n = 16), family history of kidney stones (n = 12), personal history of kidney stones (n = 11), hypertension (n = 5), uric acid stone (n = 4), race of Caucasian (n = 3), suspected kidney stone episode before the first confirmed stone episode (n = 3), surgery (n = 3), any concurrent asymptomatic (nonobstructing) stone (n = 2), pelvic or lower pole kidney stone (n = 2), and 24 h urine test completion (n = 2) were identified to be associated with KSD recurrence. In the subgroup analysis, patients with higher BMI (OR = 1.062), personal history of nephrolithiasis (OR = 1.402), or surgery (OR = 3.178) had a higher risk of radiographic KSD recurrence.
Conclusions: We identified 12 risk factors related to the recurrence of KSD. The results of this analysis could serve to construct recurrence prediction models. It could also supply a basis for preventing the recurrence of KSD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017041 | PMC |
| http://dx.doi.org/10.1186/s12894-022-01017-4 | DOI Listing |
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