AI Article Synopsis

  • * Biomimetic NPs show potential in various biomedical applications such as drug delivery, immune evasion, imaging, cancer targeting, and improving sensitivity to phototherapy.
  • * This review discusses the types of biomimetic NPs, their methods of fabrication, applications in medicine, and recent advancements in biohybrid delivery systems that utilize cell membranes.

Article Abstract

The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs) endows man-made vectors with natural capabilities and benefits. In addition to retaining the physicochemical characteristics of the NPs, the biomimetic NPs also have the functionality of source cell membranes. It has emerged as a promising approach to enhancing the properties of NPs for drug delivery, immune evasion, imaging, cancer-targeting, and phototherapy sensitivity. Several studies have been reported with a multitude of approaches to reengineering the surface of NPs using biological membranes. Owing to their low immunogenicity and intriguing biomimetic properties, cell-membrane-based biohybrid delivery systems have recently gained a lot of interest as therapeutic delivery systems. This review summarises different kinds of biomimetic NPs reported so far, their fabrication aspects, and their application in the biomedical field. Finally, it briefs on the latest advances available in this biohybrid concept.

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Source
http://dx.doi.org/10.1016/j.jconrel.2022.04.019DOI Listing

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