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| http://dx.doi.org/10.1161/CIRCHEARTFAILURE.121.009321 | DOI Listing |
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Proteomic profiling of the large-vessel vasculitis spectrum identifies shared signatures of innate immune activation and stromal remodelling.
Arthritis Rheumatol
January 2025
Department of Immunology and inflammation, Imperial College London, UK.
Background: Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large-vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments.
Methods: Plasma proteomic profiling of 184 proteins was performed in two cohorts.
Clinical Characteristics and Outcomes of Acute Myocarditis: An Analysis of Korean Multicenter Registry.
Korean Circ J
December 2024
Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Background And Objectives: Data are limited on the clinical manifestations and outcomes of acute myocarditis from a large-scale registry. We investigated acute myocarditis's clinical characteristics and prognosis from a large-scale, multi-center registry in the Republic of Korea.
Methods: We collected data from seven hospitals between 2001 and 2021.
Giant Cell Myocarditis vs Cardiac Sarcoidosis: Reconsidering the Diagnosis With FDG PET Imaging.
JACC Case Rep
November 2024
MedStar Heart and Vascular Institute, Washington, DC, USA.
Article Synopsis
- Giant cell myocarditis (GCM) and cardiac sarcoidosis have similar symptoms and tissue characteristics, leading to questions about their relationship on the inflammatory cardiomyopathy spectrum.
- The case involves a patient who experienced cardiogenic shock linked to GCM, confirmed by biopsy.
- After a heart transplant, the patient was diagnosed with sarcoidosis using 18-fluorodeoxyglucose PET imaging and another biopsy.
Long-term Functional Outcomes of Giant Cell Tumours around the Knee treated by Extended Curettage followed by Bone Grafting, Cementation, or a Combination.
Malays Orthop J
November 2024
Department of Orthopaedic Surgery, Jawaharlal Nehru Medical College and Hospital, Aligarh, India.
Introduction: Recurrence after Giant Cell Tumour (GCT) treatment depends on the type of treatment used. Poly-Methyl-Meth-Acrylate (PMMA) after extended curettage provides structural support and allows for early identification of recurrence but carries a risk of thermal damage to the surrounding healthy tissue. The aim of this study was to compare long-term functional outcomes and complications in patients with GCT around the knee treated with extended curettage and bone grafting or cementation.
View Article and Find Full Text PDFTopical 5-fluorouracil 1% as first-line therapy for giant ocular surface squamous neoplasia.
J Fr Ophtalmol
December 2024
Cornea and Refractive Surgery Department, Asociación para Evitar la Ceguera en México, I.A.P., Mexico City, Mexico.
Purpose: To evaluate the clinical outcomes of topical 5-fluorouracil (5-FU) 1% as first-line therapy for giant ocular surface squamous neoplasia (OSSN).
Materials And Methods: This was a non-comparative cohort study. We included patients with biopsy-proven giant OSSN in a tertiary-care setting.
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