AI Article Synopsis
- The study aimed to explore the link between high-risk human papilloma virus (HR-HPV) and ocular surface squamous cell neoplasia (OSSN), focusing on other potential risk factors like sun exposure and tobacco use.
- Researchers analyzed DNA from 22 OSSN tissue samples and 22 control samples to identify HPV presence and other demographic factors.
- Results indicated a significant association between HR-HPV and OSSN, with HR-HPV found in 40.9% of OSSN cases compared to just 4.5% in controls, highlighting HR-HPV as a potential cause of OSSN development.
Article Abstract
Objective: To investigate the association of high-risk hu-man papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN).
Materials And Methods: We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consump-tion information.
Results: HR-HPV frequency was 40.9% in the OSSN group and 4.5% in the pterygia group (p=0.009). After covariate adjustment, OSSN was associated with HR-HPV (OR=16.3, 95%CI=1.2,218.1, p=0.03) and sunburn (OR=10.8, 95%CI=1.8,86.0, p=0.02).
Conclusions: Ocular surface squamous cell neoplasia is a multifactorial disease. The strong association between HR-HPV and OSSN, suggests that HR-HPV could play an etiological role in OSSN development.
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| http://dx.doi.org/10.21149/12796 | DOI Listing |
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