AI Article Synopsis
- The 5-year survival rate for patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is around 50%, often due to issues like tumor progression and resistance to chemotherapy.
- Researchers analyzed the expression of certain cytochrome P450 (CYP) enzymes in tumor tissue versus non-cancerous tissue in NRSTS patients using qPCR and Western blot methods.
- The study found significantly higher levels of CYP1B1, CYP2E1, and CYP3A4 in tumor tissues, suggesting their involvement in cancer development and the chemoresistance observed in these patients.
Article Abstract
The 5-year relative survival rate estimate of treated patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is ∼50% since they generally present with tumor progression, relapse, metastasis, and/or chemoresistance. The expression of cytochrome P450 (CYP) enzymes in malignancies can affect the pharmacology of drugs commonly used in chemotherapy or confer susceptibility to development of chemical carcinogenesis; in addition, their specific tumor expression can be used as a therapeutic target. Using qPCR and Western blot assays, the expression of CYP1B1, CYP2E1, CYP3A4, and CYP3A5 were analyzed in a cohort of tumor tissue paired with non-malignant adjacent tissue of patients with NRSTS. The mRNA and protein expression of CYP1B1, CYP2E1, and CYP3A4 were significantly increased in tumor tissue. We propose that the expression of these isoforms is related to carcinogenesis and chemoresistance frequently observed in these neoplasms.
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| http://dx.doi.org/10.1177/10915818221085909 | DOI Listing |
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