Inverse Kinematics (IK) is an optimisation to estimate joint angles from motion capture data, where marker trajectories and weighting strategies determine the outcome. Skin-mounted markers are subject to Soft Tissue Artefact (STA), particularly thigh markers. Our first aim was to test the effect of neglecting thigh markers on IK results across different markersets. Our second aim was to investigate inter-markerset differences using varying weighting strategies. Twenty participants participated in a treadmill walking motion capture session. Inverse kinematic analysis was performed using three markersets, termed Contemporary (segment clusters), NoThigh (Contemporary without thigh markers), and Traditional (modified Helen Hayes). Seven weighting schemes were used with varying magnitudes with each markerset. Joint angles (comprising tri-planar hip angles, and sagittal knee and ankle angles) were compared across all three conditions. NoThigh and Traditional generated joint angle results that differed from the Contemporary markerset by a median of 1.2° and 1.5°, respectively. Non-sagittal hip angles differed the most. Most average joint angle differences were smaller than previously-estimated STA error. NoThigh generated less difference from Contemporary than Traditional for the hip and knee joints. Intuitively, weighting strategies that heavily favour shared markers resulted in IK results with closer inter-markerset agreement. Thigh markers can be neglected without introducing more error than STA, and different markersets (with validation) can be compared against each other when using strategic weighting. This creates new research pathways for collaboration and data re-use, as well as freeing researchers (and participants) of their attachment to thigh markers.
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http://dx.doi.org/10.1016/j.jbiomech.2022.111086 | DOI Listing |
Laryngoscope Investig Otolaryngol
February 2025
Background: The main technique for identification of free flap perforator vessels is Doppler sonography, which is not always accurate, user dependent and affected by the patient's body habitus.
Methods: Adult patients undergoing head and neck resection and free flap reconstruction at two academic institutions were enrolled. Doppler sonography was used to identify perforators, and were marked using a skin marker.
Neurology
February 2025
From the Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.
Background And Objectives: Lewy body diseases (LBDs) such as Parkinson disease (PD) feature increased deposition of α-synuclein (α-syn) in cutaneous sympathetic noradrenergic nerves. The pathophysiologic significance of sympathetic intraneuronal α-syn is unclear. We reviewed data about immunoreactive α-syn, tyrosine hydroxylase (TH, a marker of catecholaminergic fibers), and the sympathetic neurotransmitter norepinephrine (NE) in skin biopsies from control participants and patients with PD, the related LBD pure autonomic failure (PAF), the non-LBD synucleinopathy multiple system atrophy (MSA), or neurologic postacute sequelae of severe acute respiratory syndrome coronavirus 2 (neuro-PASC).
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a rare condition caused by an immune response associated with over-reactivity of the immune system, triggered by adjuvants. The most common adjuvants are aluminium salts but can also be bioimplants or infectious agents. It may lead to the development of various autoimmunologic diseases.
View Article and Find Full Text PDFCureus
December 2024
Pediatric Medicine, Tawam Hospital, Abu Dhabi, ARE.
Arch Razi Inst
June 2024
Department of Pharmacy Practice, K.K. College of Pharmacy, The Tamil Nadu Dr. M.G.R. Medical University, Chennai, India.
Cancer, a disease threatening human life, is caused by the disturbance of the normal cell cycle, which results in the spontaneous growth of normal and malignant cells, the lack of differentiation between the two, and consequently malignant growths. Nowadays, various synthetic agents are applied for cancer therapy; nevertheless, reports have confirmed that these chemical agents are associated with various adverse complications. This experimental study was designed to assess the anti-tumor activities of zinc nanoparticles (ZnNPs) green synthesized by the () extract against Ehrlich solid tumors (EST) in mice.
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