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Background: The use of phytosanitary products is always associated with their safety concern on the environment and on health. The associated adverse effects are very broad and substance-dependent. Among these substances, epoxiconazole (EPOX) is one of the most widely used fungicides, especially in beet crops. Although its use is questionable or even prohibited in the European Union, it is still widely used and its consequences (transgenerational effects) on future generations is unknown.
Objectives: We aimed to investigate the hepatic effects of epoxiconazole in the descendants of perinatally exposed low-dose C57Bl/6J mice, focusing on liver histological and transcriptomic analyses.
Methods: From day 0 of gestation up to day 21 postnatal, only pregnant F0 C57BL6/J mice were exposed to EPOX (1.75 μg/kg bw/day). F1 males and females were mated to obtain the F2 generation and similarly, F2 mice were crossed to obtain F3. Histological and transcriptomic analyses of the liver were performed. Gene set enrichment analysis was realized to determine an a priori defined set of genes with significantly altered mRNA expression. Plasma parameters were also measured.
Results And Conclusion: s: Perinatal exposure to EPOX induces transgenerational effects with phenotypic, histological and transcriptomic changes in the liver. These changes are highly dependent on the sex and generation of the animal. All these modifications lead to an alteration of the hepatic metabolism resulting in a difference in the size of the hepatocytes. Beyond these specific mechanisms, EPOX also seems to have a more general impact on hepatic metabolism via the circadian rhythm.
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http://dx.doi.org/10.1016/j.cbi.2022.109952 | DOI Listing |
Front Immunol
December 2024
South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, Guangzhou, China.
Ammonia-N stress is a significant environmental factor that adversely affects the health and productivity of aquaculture species. This study investigates the effects of ammonia-N stress on the shrimp through a combination of biochemical, histological, transcriptomic, and metabolomic analyses. Shrimp were exposed to ammonia-N stress for 12 and 96 hours, and key markers of oxidative stress, nitrogen metabolism, immune response, and overall health were assessed.
View Article and Find Full Text PDFBiomaterials
December 2024
Institut de Science des Matériaux de Mulhouse (IS2M), UMR 7361 CNRS/, Université de Haute Alsace (UHA), 15 rue Jean Starcky, 68057, Mulhouse Cedex, France. Electronic address:
Silicone-based breast implants are commonly used, but there are concerns about their long-term safety. While implantation results in the formation of a periprosthetic tissue that isolates the implant from the rest of the host body, silicone can leak and reach surrounding tissues. We combined histological analysis and gene expression profiling (RNA sequencing) of samples from human patients with silicone breast implants with different fillers (silicone or serum), surface topographies and/or shell rupture, and performed systematic cross-comparisons.
View Article and Find Full Text PDFRedox Biol
December 2024
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, 430030, PR China; Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China. Electronic address:
Background: Oxidative stress and microglial activation are critical pathomechanisms in ischemic white matter injury. Microglia, as resident immune cells in the brain, are the main cells undergoing oxidative stress response. However, the role and molecular mechanism of oxidative stress in microglia have not been clearly elucidated during white matter ischemia.
View Article and Find Full Text PDFComput Struct Biotechnol J
December 2024
School of Information Science and Engineering, Yunnan University, Kunming, 650091, Yunnan, China.
The rapid development of spatial transcriptomics (ST) technology has provided unprecedented opportunities to understand tissue relationships and functions within specific spatial contexts. Accurate identification of spatial domains is crucial for downstream spatial transcriptomics analysis. However, effectively combining gene expression data, histological images and spatial coordinate data to identify spatial domains remains a challenge.
View Article and Find Full Text PDFBrain Pathol
December 2024
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Brain injury represents the leading cause of mortality and disability after cardiopulmonary resuscitation (CPR) from cardiac arrest (CA), in which the accumulation of dying cells aggravate tissue injury by releasing proinflammatory intracellular components. Microglia play an essential role in maintaining brain homeostasis via milk fat globule epidermal growth factor 8 (MFG-E8)-opsonized efferocytosis, the engulfment of dying cells and debris. This study investigates whether potentiating microglia efferocytosis by MFG-E8 provides neuroprotection after CA/CPR.
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