AI Article Synopsis
- The dopamine D3 receptor (D3R) is key in managing cognitive functions in both healthy individuals and those with neuropsychiatric disorders.
- Blocking the D3R has shown promise in improving cognitive performance, but not all approaches targeting this receptor are effective since some can act as partial agonists that also help maintain dopamine levels.
- The chapter explores various studies to emphasize the importance of D3R in cognition and suggests that drugs targeting this receptor could be effective treatments for cognitive issues in various disorders.
Article Abstract
The dopamine D3 receptor (D3R) plays a prominent role in the modulation of cognition in healthy individuals, as well as in the pathophysiological mechanism underlying the cognitive deficits affecting patients suffering from neuropsychiatric disorders. At a therapeutic level, a growing body of evidence suggests that the D3R blockade enhances cognitive and thus it may be an optimal therapeutic strategy against cognitive dysfunctions. However, this is not always the case because other ligands targeting the D3R, and behaving as partial agonists or biased agonists, may exert their pro-cognitive effect by maintaining adequate level of dopamine in key brain areas tuning cognitive performances. In this chapter, we review and discuss preclinical and clinical findings with the aim to remark the crucial role of the D3R in cognition and to strengthen the message that drugs targeting D3R may be excellent cognitive enhancers for the treatment of several neuropsychiatric and neurological disorders.
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| http://dx.doi.org/10.1007/7854_2022_326 | DOI Listing |
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