Capacitive and resistive electric transfer (CRET) therapy is used to reduce pain and improve functional disability, and the effect on low back pain remains to be investigated. This study aimed to examine the immediate effect on the onset time of the muscles after irradiating CRET therapy for non-specific chronic low back pain (NSCLBP). Thirty patients with NSCLBP were randomly divided into an intervention group (n = 15) and a sham group (n = 15). Participants and statisticians were blinded to participant allocation. The intervention group received one 15-minute session of CRET therapy on their lower back; the sham group similarly received one 15-minute session of sham therapy. Before and immediately after the intervention, the onset time of the trunk and lower limb muscles was measured during prone hip extension, and pain intensity was recorded using a visual analog scale. The intervention group showed a significant reduction in pain and a significantly earlier onset time of the thoracic part of the iliocostalis lumborum, lumbar part of the iliocostalis lumborum, lumbar multifidus, and gluteus maximus. These results showed that CRET therapy not only reduced pain, but also facilitated trunk muscle activity. Improvement in muscle activity patterns may improve activities of daily living. This study was registered at the University Hospital Medical Information Network in Japan (UMIN-CTR: 000046301).
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http://dx.doi.org/10.1080/15368378.2022.2065681 | DOI Listing |
J Biochem Mol Toxicol
December 2024
Department of Pharmacy,Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Nephrotoxicity is a prominent complication of methotrexate (MTX) therapy that limits clinicians in its extensive use. MTX triggers oxidative burden and inflammation, so the nephroprotective potential of the synthetic derivative of 1,3,4-oxadiazole (5b) was explored in this research. Male Wistar rats were divided into four groups i.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
November 2024
CAS Key Laboratory of Nano-Bio Interface, Suzhou Key Laboratory of Functional Molecular Imaging Technology, Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
Sentinel lymph node (SLN) biopsy is currently the standard procedure for clinical cancer diagnosis and treatment, but still faces the risks of false negatives and tumor metastasis, as well as time-consuming pathological evaluation procedure. Herein, we proposed a near-infrared-II (NIR-II, 1000-1700 nm) theranostic nanosystem (FLAGC) for rapid, non-invasive, accurate diagnosis and efficient clearance of metastatic lymph nodes in breast cancer. Initialized by chlorin e6 (Ce6), a pH-sensitive amphiphilic amino acid fluorenylmethoxycarbonyl-L-histidine (Fmoc-His) was assembled with Gd, luminol, and AgAuSe quantum dots (AAS QDs) to form FLAGC.
View Article and Find Full Text PDFInt J Mol Sci
October 2024
Photobiology and Bioelectromagnetic Lab, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Ramón y Cajal, Crta. Colmenar Viejo, km. 9.100, 28034 Madrid, Spain.
Keratinocytes play an essential role in the inflammatory phase of wound regeneration. In addition to migrating and proliferating for tissue regeneration, they produce a large amount of cytokines that modulate the inflammatory process. Previous studies have shown that subthermal treatment with radiofrequency (RF) currents used in capacitive resistive electric transfer (CRET) therapy promotes the proliferation of HaCat keratinocytes and modulates their cytokine production.
View Article and Find Full Text PDFRev Med Suisse
September 2024
Pharmacie interhospitalière de la Côte, Ch. du Crêt 2, 1110 Morges.
The mechanism of action of selective serotonin reuptake inhibitors (SSRI) is still not properly established. It is essential to consider their positive and negative side effects before prescribing. In this article, we describe several of these side effects in the context of common pathologies and clinical situations.
View Article and Find Full Text PDFCurr Cardiol Rep
November 2024
Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Purpose Of Review: Considerable current interest is directed at pharmacological agents for producing significant weight loss. However, healthy lifestyle choices can also lead to clinically meaningful weight loss and improvements in cardiovascular disease (CVD) risk factors.
Recent Findings: In this review, we summarize the recent research from our PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) randomized controlled trial and review previous data on the potential benefits of cardiac rehabilitation and exercise training (CRET) programs to produce weight loss and improvements in CVD risk factors.
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