Autologous platelet-rich plasma 'fluid' versus 'gel' form in combination with fractional CO laser in the treatment of atrophic acne scars: a split-face randomized clinical trial.

Background: The treatment of atrophic acne scars represents a therapeutic challenge. Recently, plasma gel has been introduced among treatment modalities.

Objective: To compare the efficacy of platelet-rich-plasma 'fluid' versus 'gel' form combined with fractional CO laser in the treatment of atrophic acne scars.

Methods: Twenty-seven patients with atrophic acne scars were included. Treatment with fractional CO laser plus plasma fluid/gel was randomly assigned to the right/left sides of the face. Clinical and Optical Coherence Tomography (OCT) assessments were scheduled at baseline, one month, and three months after the last session.

Results: There was a significant improvement in clinical assessment scores at third-month follow-up on the plasma gel- and plasma fluid-treated sides compared to those at the first-month follow-up (001). Scar depth decreased significantly at third-month follow-up when compared to baseline on both plasma gel- and plasma fluid-treated sides (001). The numerical pain score was significantly lower on the plasma fluid-treated side compared to the plasma gel-treated side (004).

Conclusion: The use of platelet-rich plasma in combination with fractional CO laser, both in fluid and gel form, produced significant results in the treatment of atrophic acne scars. Patients reported an immediate more noticeable effect with plasma gel. However, the fluid injection was less painful.