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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545130 | PMC |
| http://dx.doi.org/10.1111/dom.14718 | DOI Listing |
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Guselkumab: A New Therapeutic Option for the Treatment of Moderately to Severely Active Ulcerative Colitis.
Ann Pharmacother
January 2025
Inflammatory Bowel Disease Center, The University of Chicago Medicine, Chicago, IL, USA.
Objective: To summarize the evidence and pharmacologic profile of guselkumab for moderate to severe ulcerative colitis (UC).
Data Sources: A PubMed search from inception to end of October 2024 using keywords was conducted. Additional information was obtained from abstracts and package insert.
Critical Review: Considerations in Applying Avian Egg Injection Studies to Characterize Effects of Hydrophobic Organic Compounds on Wild Birds.
Chemosphere
January 2025
Ramboll, 3401 Enterprise Place, Suite 340, Beachwood, Ohio 44122, USA. Electronic address:
Egg injection has been used for decades to determine embryonic mortality and developmental effects of chemical exposures in birds. Specific egg injection methods affect how well these studies replicate the process of chemical delivery to the embryo via maternal deposition, yet few data are available to compare exposure-response relationships between egg injection and maternal transfer studies. This information gap creates uncertainty when considering egg injection studies for assessment of potential adverse effects in wild birds.
View Article and Find Full Text PDFIntroduction: Hemodialysis patients need long-term frequent use of parenteral anticoagulants, and the side effects need to be taken seriously. This study aimed to assess the reporting of adverse drug reactions (ADRs) following administration of unfractionated heparin (UFH), low molecular weight heparins (LMWHs), fondaparinux, and danaparoid, in relation to their usage in European Economic Area (EEA).
Materials And Methods: The total number of ADRs of each anticoagulant between 2017 to 2021 was collected using data from the EudraVigilance database.
National Beef Quality Audit-2022: Harvest-floor assessments of hide defects, carcass defects, and offal condemnations that affect value of carcasses and by-products from market cows and bulls.
Transl Anim Sci
December 2024
Department of Animal Science, Texas A&M AgriLife Research, Texas A&M University, College Station, TX 77843-2471, USA.
The National Beef Quality Audit ()-2022 serves as a benchmark of the current market cow and bull sectors of the U.S. beef industry and allows comparison to previous audits as a method of monitoring industry progress.
View Article and Find Full Text PDFUrodynamic Changes Following Fewer Injection Sites of Intravesical Botulinum Toxin in Idiopathic Detrusor Overactivity: A Double-Blinded Prospective Randomized Clinical Trial.
Int Urogynecol J
January 2025
Department of Urology, Hasheminejad Kidney Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Introduction And Hypothesis: This study was aimed at evaluating the therapeutic effects of a modified intravesical botulinum toxin injection technique (fewer injection sites under local anesthesia), in comparison with the conventional technique for patients with idiopathic detrusor overactivity, considering the urodynamic parameters.
Methods: In this double-blinded randomized clinical trial, 78 adult females with idiopathic detrusor overactivity were divided into two groups: conventional and modified groups. In the conventional method, patients received intradetrusor botulinum toxin injection at 20 sites under general or spinal anesthesia in a trigone-sparing fashion.
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