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Optimizing controlled degradation, bioactivity, and mechanical behavior in sol-gel synthesized aluminum titanate biomaterials.
Biomed Mater
March 2025
Department of Physics, Manonmaniam Sundaranar University, Tirunelveli 627012, Tamil Nadu, India.
Orthopaedic applications require materials that balance mechanical strength, biocompatibility, and controlled degradation, particularly for bone regeneration and load-bearing purposes. This study investigates the effects of varying weight percentages of AlOand TiO(25:75, 50:50, and 75:25) on the characteristics of AlTiObiomaterials synthesized via the sol-gel method. Structural and chemical characterizations, including XRD and FTIR, confirmed the successful synthesis of phase-pure AlTiO, highlighting functional groups such as Al-O and Ti-O.
View Article and Find Full Text PDFBioactivity Assessment of Functionalized TiO Powder with Dihydroquercetin.
Int J Mol Sci
February 2025
Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia, Centre of Excellence for Photoconversion, University of Belgrade, 11351 Belgrade, Serbia.
Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO, its inorganic component. Pristine TiO did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1-20 mg/mL), while TiO/DHQ displayed a significant reduction in cell viability in both cell lines at higher concentrations (≥10 mg/mL). The analysis of reactive oxygen species (ROS) production revealed that TiO/DHQ significantly reduced ROS levels in both cell types (MRC-5 and HeLa), with HeLa cells showing a more substantial reduction at lower concentrations.
View Article and Find Full Text PDFMutations in the riboflavin biosynthesis pathway confer resistance to furazolidone and abolish the synergistic interaction between furazolidone and vancomycin in .
Microb Genom
February 2025
School of Food Technology and Natural Sciences, Massey University, Palmerston North, New Zealand.
The combined application of furazolidone and vancomycin has previously been shown to be synergistic against Gram-negative pathogens, with great therapeutic promise. However, the emergence and mechanism of resistance to this antibiotic combination have not been characterized. To fill this gap, we here selected progeny for growth on the furazolidone-vancomycin combination at the concentration where the parent was sensitive.
View Article and Find Full Text PDFFungal derived dye as potential photosensitizer for antimicrobial photodynamic therapy.
J Photochem Photobiol B
March 2025
Department of Bioprocess Engineering and Biotechnology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil. Electronic address:
Photodynamic therapy (PDT) combines light with a photosensitizing agent to target and destroy abnormal cells or pathogens, offering a non-invasive and precise approach. Applying microbial dyes in PDT presents a great opportunity because these compounds may absorb specific wavelengths of light, generating reactive oxygen species (ROS) that induce oxidative stress, leading to cell or microbial death. This study evaluated the extract of Talaromyces amestolkiae containing azaphilone red dyes obtained from cultivation process as photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT).
View Article and Find Full Text PDFProduction of the recombinant human riboflavin transporters SLC52A1, 3 and functional assay in proteoliposomes.
Arch Biochem Biophys
April 2025
Department DiBEST (Biologia, Ecologia e Scienze della Terra), University of Calabria, Arcavacata di Rende, Italy; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnology, Bari, Italy. Electronic address:
Riboflavin, the FMN and FAD precursor, is a crucial vitamin in cell metabolism. Its adsorption and tissue distribution are mediated by tree membrane transporters namely RFVT1-3. Mutations of their genes are associated with Riboflavin Transporter Deficiency.
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