AI Article Synopsis
- The study investigates the radio-protective effects of Mentha-Pulegium essential oil (MP-EO) on human peripheral blood mononuclear cells (PBMCs) exposed to X-ray radiation.
- Results showed that MP-EO significantly increased the survival rates of irradiated PBMCs and reduced the rates of apoptosis and necrosis after specific radiation doses and incubation times.
- The findings suggest that MP-EO could serve as a natural and safe compound for protecting cells from the damaging effects of ionizing radiation.
Article Abstract
Background: The Mentha-Pulegium essential oil (MP-EO) contains different antioxidant compounds and reduces the indirect effects of dispersed ionizing radiation on biological systems.
Objective: The current study aimed to assess a possible radio-protective effect of MP-EO on peripheral blood mononuclear cells (PBMCs).
Material And Methods: In this experimental study, MP-EO was firstly prepared and PBMCs were then irradiated in various groups with doses of 25 and 200 cGy of X-rays in the presence of of MP-EO. After incubation times of 48h and 72h, the survival, apoptosis, and necrosis percentages of PBMCs were determined by MTT assay and flow cytometry analyses; the radio-protective effect of MP-EO was examined.
Results: In the presence of 80 µg/ml () MP-EO, the mean survival percentage of irradiated PBMCs by radiation doses of 25 and 200 cGy was significantly increased after 48h of incubation compared with the control. At 72h of incubation, the mean survival percentage of irradiated PBMCs was significantly increased only at 25 cGy. The percentage of apoptosis and necrosis of PBMCs was significantly reduced in the presence of the MP-EO at both incubation times and radiation doses; therefore, the highest reduction was at 200 cGy and 48h incubation compared to the control.
Conclusion: MP-EO as a natural, non-toxic, and cost-effective compound can exhibit a favorable radio-protective effect by increasing the survival and decreasing the percentage of apoptosis and necrosis of irradiated PBMCs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995758 | PMC |
| http://dx.doi.org/10.31661/jbpe.v0i0.2109-1397 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of cold plasma-assisted Non-thermal deamidation and glycosylation on the construction of sugar derivative-zein conjugates for enhancing pickering foam stability: Technical principles and molecular interactions.
Food Res Int
January 2025
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, No. 9, No. 13 Ave., TEDA, Tianjin 300457, China. Electronic address:
There is an urgent need for stable, plant-based Pickering foams to address the growing consumer demand for sustainable, low-calorie, aerated sweet foods. This study employed a cold plasma-assisted deamidation and glycosylation (CPDG) approach to promote hydrophilic reassembly of zein, resulting in the formation of sugar derivative-zein conjugates. This was accomplished by coupling deamidated zein with polyhydroxy sugars including sucralose (Suc), maltitol (Mal), mannitol (Man), and stevioside (Ste).
View Article and Find Full Text PDFImpact of Radiotherapy on Endocrine Function and Gut Microbiota in Cervical Cancer Patients Undergoing Ovarian Transposition.
Int J Womens Health
December 2024
Emergency Room, Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang, People's Republic of China.
Article Synopsis
- The study compares the effects of radiotherapy on ovarian and endocrine functions as well as gut microbiota in cervical cancer patients with and without ovarian transposition.
- The results indicated that patients who underwent ovarian transposition had better ovarian function preservation and improved quality of life scores compared to those who did not.
- Additionally, gut microbiota analysis showed distinct differences in microbial composition between the two groups, indicating the potential impact of ovarian transposition on gut health.
Application value of personalized 3D printing vaginal model for the Image-guided adaptive brachytherapy of cervical cancer.
J Gynecol Oncol
November 2024
The 3th Ward of Radiotherapy Department, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.
Objective: To explore the application value of using 3-dimensional (3D) printing (3DP) technology to create individualized vaginal molds for brachytherapy (BT) in high-dose-rate 3D cervical cancer through reverse engineering of needle placement.
Methods: Prospectively, 11 patients with cervical cancer were treated with 3DP-intracavitary/interstitial (IC/IS) BT using 3DP to create individualized vaginal molds. All patients were performed BT after completion of external beam radiotherapy (EBRT).
Dosimetric comparison between single-channel vaginal cylinder and free-hand interstitial needles in vaginal brachytherapy of gynecological cancers.
J Contemp Brachytherapy
June 2024
Fujian Provincial Cancer Hospital, Jinan District, Fujian Province Fuzhou, 350014 Fuzhou City, China.
Article Synopsis
- - The study aimed to compare dosimetric outcomes of vaginal brachytherapy using two methods: single-channel vaginal cylinder (SCVC) and free-hand interstitial needles (FIN) in treating gynecologic tumors after surgery and external beam radiation therapy.
- - Out of 22 women treated, both methods achieved similar coverage of the high-risk clinical target volume (HR-CTV), but the FIN technique had better dose distribution and resulted in lower doses to critical organs like the rectum and bladder compared to SCVC.
- - The findings suggest that the FIN technique is a more effective option for high-dose-rate vaginal brachytherapy in minimizing radiation exposure to surrounding organs while ensuring adequate treatment coverage.
AVATAR 2.0: next level communication systems for radiotherapy through face-to-face video, biofeedback, translation, and audiovisual immersion.
Front Oncol
October 2024
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States.
Purpose: This paper discusses an advanced version of our audiovisual-assisted therapeutic ambience in radiotherapy (AVATAR) radiolucent display systems designed for pediatric radiotherapy, enabling anesthesia-free treatments, video communication, and biofeedback. The scope of the AVATAR system is expanded here in two major ways: (i) through alternative mounting systems to accommodate a broader range of radiotherapy machines (specifically to fit robotic-arm and toroidal geometry photon radiotherapy and proton radiotherapy systems) and (ii) through additional hardware to provide video-calling, optimized audio for clear communication, and combined video inputs for biofeedback, translation, and other advanced functionalities.
Methods And Materials: Because robustness requires strong parts and radio-transparency requires thin, light parts, three-dimensional printing was used to rapidly prototype hollow structures and to iteratively improve robustness.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!