AI Article Synopsis
- Sepsis is a complex disease with varying symptoms and outcomes, increasing the risk of mortality, thus requiring structured treatment protocols.
- All patients should receive essential management strategies, including infection control, resuscitation, and support for multiple organs.
- Certain patient subgroups may benefit from tailored therapies targeting their specific conditions; while some methods are still being researched, others are already in clinical use to improve treatment outcomes.
Article Abstract
Sepsis is a heterogeneous disease with variable clinical course and several clinical phenotypes. As it is associated with an increased risk of death, patients with this condition are candidates for receipt of a very well-structured and protocolized treatment. All patients should receive the fundamental pillars of sepsis management, which are infection control, initial resuscitation, and multiorgan support. However, specific subgroups of patients may benefit from a personalized approach with interventions targeted towards specific pathophysiological mechanisms. Herein, we will review the framework for identifying subpopulations of patients with sepsis, septic shock, and multiorgan dysfunction who may benefit from specific therapies. Some of these approaches are still in the early stages of research, while others are already in routine use in clinical practice, but together will help in the effective generation and safe implementation of precision medicine in sepsis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788206 | PMC |
| http://dx.doi.org/10.5492/wjccm.v11.i1.1 | DOI Listing |
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