AI Article Synopsis
- The study investigated the neurodevelopment of children conceived through in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) compared to those conceived naturally.
- Data from a large Japanese birth cohort was analyzed, focusing on over 77,000 children, with specific attention to developmental delays identified at age 3.
- The findings indicated that while children conceived via IVF or ICSI had higher odds of developmental delays in a crude model, these risks leveled out when accounting for parental factors and sex, suggesting that infertility-related factors rather than the conception method may play a larger role.
Article Abstract
Purpose: This study aimed to investigate neurodevelopment in children conceived via fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with several types of embryo transfers.
Methods: We analyzed data for 77 928 children and their mothers included in a Japanese birth cohort study. Among the included children, 4071 were conceived via IVF, while 1542 were conceived via ICSI. Neurodevelopmental delay at the age of 3 years was assessed using the Japanese version of the Ages and Stages Questionnaires, 3rd edition.
Results: In the crude model, the odds ratios for developmental delay in 1-4 domains were higher among children conceived via IVF, ICSI, and non-ART (ovulatory induction or intrauterine insemination) than in spontaneously conceived children. After adjusting for parental background factors and the child's sex, there were no differences in the risk of developmental delay when comparing singletons conceived by IVF, ICSI, or non-ART and those conceived spontaneously. Higher odds ratios for developmental delay in one domain were observed in singleton girls conceived via IVF when compared with those who were spontaneously conceived.
Conclusion: Most cases of developmental delay may be associated with multiple pregnancies and factors related to infertility, such as parental age, irrespective of the use of ART.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002241 | PMC |
| http://dx.doi.org/10.1002/rmb2.12457 | DOI Listing |
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