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Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states. | LitMetric

AI Article Synopsis

  • * There was a significant relationship between TL and endotoxin levels, especially in obese individuals, with endotoxin acting as a predictor of TL across all subjects.
  • * Additionally, in non-T2DM participants, TL and HDL-cholesterol together explained a notable portion of the variance in vitamin D levels, suggesting the importance of gut health and vitamin D in combating premature cellular aging linked to obesity and metabolic health.

Article Abstract

There are limited studies on the association of endotoxin, a potent mediator of gut-derived inflammation and telomere length (TL). We investigated (1) the influence of adiposity on endotoxin and TL amongst Saudi adults according to type 2 diabetes mellitus (T2DM) status and (2) the influence vitamin D may have on TL attrition. Anthropometric data and fasting blood samples were taken from 775 Saudi adults visiting different primary care centers in Riyadh [387 T2DM and 388 non-T2DM]. TL, derived from peripheral blood mononuclear cells, was analyzed by Quantitative real-time polymerase chain reaction and circulating endotoxin levels by Limulus Amebocyte Lysate assay. Subjects were stratified based on obesity and T2DM status. A significant lower TL was observed in the non-obese T2DM group as compared with their non-obese, non-T2DM counterparts (p = 0.002). Significant inverse associations between TL, endotoxin and endotoxin activity were observed in the cohort with obesity. Regression analysis showed that endotoxin was a significant predictor for TL in all subjects and even after stratification according to subgroups; with variances perceived in circulating TL stronger among non-T2DM obese (10%; p = 0.003) than non-T2DM non-obese (12%; p = 0.007). Also, in the non-T2DM group, TL and HDL-cholesterol predicted 29% of the variances perceived in 25(OH)D (p < 0.001). Taken together these findings show that circulating endotoxin and 25(OH)D are associated with premature biological ageing influenced by adiposity and metabolic state; suggesting future intervention studies to manipulate gut microbiome and or vitamin D levels may offer ways to mitigate premature TL attrition.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011112PMC
http://dx.doi.org/10.1016/j.sjbs.2022.03.026DOI Listing

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