Objective: The objective of this study is to develop novel CaF/SiO nanoclusters (NCs) fillers, which can endow the dental resin composites (DRCs) with excellent mechanical properties, stable and sustained fluoride ion release, and good antibacterial activity.
Methods: The CaF/SiO NCs were efficiently fabricated by assembling CaF/SiO nanoparticles (NPs) as building blocks with a spray-drying technology. CaF/SiO NCs with different SiO coating amounts (20 wt%, 50 wt% and 80 wt%) were incorporated into the DRCs at the filler content of 55 wt% for the measurement of mechanical properties including flexural strength, flexural modulus, compressive strength, and hardness. The effect of the filling amount of CaF/50SiO NCs (50 represents 50 wt% SiO coating amount) in the DRCs was investigated, while CaF/50SiO NPs were adopted as comparison group. The fluoride ion release and antibacterial activity of the DRCs with the optimal mechanical performances were evaluated. Furthermore, the statistical analyses were performed for mechanical properties.
Results: Spherical CaF/50SiO NCs with an average size of 2.4 µm were obtained at the feed rate of 7.4 mL/min and the CaF/50SiO NPs solid content of 2 wt% in the suspension. The optimum comprehensive performances of the DRCs can be achieved by filling 55 wt% CaF/50SiO NCs. Compared with CaF/50SiO NPs, the filling amount of CaF/50SiO NCs was increased by 5 wt% (50-55 wt%), and under the same filling amount of 50 wt%, the flexural strength, flexural modulus, compressive strength, and hardness of the DRCs containing CaF/50SiO NCs were improved by 9.8%, 17.7%, 7.5% and 69.8%, respectively. Furthermore, the DRCs filled with 50 wt% CaF/50SiO NCs exhibited more cumulative F-release by 126% and more stable F-release rate than the counterpart filled with 50 wt% CaF/50SiO NPs after immersed for 1800 h. And 55 wt% CaF/50SiO NCs filled DRCs could inhibit the growth of S. mutans, reaching an antibacterial ratio of 93%.
Significance: The spray-dried CaF/50SiO NCs are promising fillers for the development of high-performance multifunctional DRCs.
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| http://dx.doi.org/10.1016/j.dental.2022.04.007 | DOI Listing |
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Spray-drying-assisted fabrication of CaF/SiO nanoclusters for dental restorative composites.
Dent Mater
May 2022
State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, PR China; Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:
Objective: The objective of this study is to develop novel CaF/SiO nanoclusters (NCs) fillers, which can endow the dental resin composites (DRCs) with excellent mechanical properties, stable and sustained fluoride ion release, and good antibacterial activity.
Methods: The CaF/SiO NCs were efficiently fabricated by assembling CaF/SiO nanoparticles (NPs) as building blocks with a spray-drying technology. CaF/SiO NCs with different SiO coating amounts (20 wt%, 50 wt% and 80 wt%) were incorporated into the DRCs at the filler content of 55 wt% for the measurement of mechanical properties including flexural strength, flexural modulus, compressive strength, and hardness.
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