Purpose: This study aimed to investigate the clinical features and risk factors for poor visual outcomes in patients with endogenous Klebsiella pneumoniae endophthalmitis (EKE).
Methods: This retrospective interventional case series reviewed the medical records of 17 patients (21 eyes) with EKE from January 2007 to December 2019. Clinical findings, treatments, visual outcomes, and potential prognostic factors were evaluated.
Results: The mean age of the patients was 55.9 years and 13 patients (76.5%) were males. Diabetes (23.5%) was the most commonly associated systemic disease and liver abscess (70.6%) was the major infection source. Poor initial visual acuity worse than counting fingers was significantly associated with poor final visual outcome (p = 0.003). In this study, adjunctive intravitreal dexamethasone injection and primary vitrectomy were not associated with final visual outcome. Secondary enucleation/evisceration was performed in 14.3%.
Conclusions: EKE usually has a poor visual prognosis, and early diagnosis with fair initial visual acuity would be crucial in saving vision.
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http://dx.doi.org/10.1007/s10792-022-02301-w | DOI Listing |
Biomedicines
November 2024
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.
Background: Chronic sleep deprivation (CSD) plays an important role in mood disorders. However, the changes in the gut microbiota and metabolites associated with CSD-induced anxiety/depression-like behavior in female mice have not been determined. Due to the influence of endogenous hormone levels, females are more susceptible than males to negative emotions caused by sleep deprivation.
View Article and Find Full Text PDFBMC Res Notes
December 2024
Department of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Background: The nasopharynx is characterised by a rich microbial diversity, making it an important endogenous reservoir for respiratory infections. People living with diabetes (PLWD) have a high risk for acquisition of respiratory tract infections, but their nasopharyngeal bacterial flora have rarely been investigated.
Aim: To investigate the nasopharyngeal bacterial flora among PLWD and non-diabetics at the Korle Bu Teaching Hospital in Accra.
Ophthalmologica
December 2024
Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Introduction: Infectious endophthalmitis, a vision-threatening disease caused by exogenous or endogenous microbial invasion, may require vitrectomy with or without silicone oil (SO) tamponade in severe cases. SO antimicrobial effects have been suggested but not demonstrated in an in vitro environment mimicking real clinical conditions. Using an in vitro intraocular tamponade model, we investigated the antimicrobial activity of SO against 11 bacterial and 1 fungal species, including antibiotic-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae.
View Article and Find Full Text PDFIndian J Nephrol
September 2024
Department of Nephrology, NU Hospitals, Bangalore, India.
Blood stream infections (BSI) are common in patients with kidney disease. Metastatic foci of infections are one of the known complications of BSI. Endophthalmitis which is defined as infection and inflammation of the inner coats of the eye ball and intraocular fluids (aqueous and vitreous), is one such focus.
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