AI Article Synopsis
- Leptomeres are thin, layered structures made of fine filaments, frequently found in cultured muscle fibers of patients with specific muscle disorders.
- They were commonly seen in those with acid maltase deficiency and other myopathies, but only rarely in cultures of normal muscle.
- Leptomeres could also be created in normal muscle cultures when exposed to a chemical called DNP at a concentration of 0.5 mM.
Article Abstract
Leptomeres, the laminated structures consisting of bundles of very fine filaments separated into bands about 260 nm wide by periodic transverse dense lines 20--80 nm wide, were observed frequently in cultured muscle fibers of 8 patients with acid maltase deficiency, 4 with sporadic, adult-onset idiopathic "autophagic" vacuolar myopathy (that is not acid-maltase deficient) and one with abnormal mitochondria, but in only one of greater than 50 other cultures of normal and denervated human muscle. They were also induced abundantly in cultured normal human muscle by exposure to 0.5 mM DNP.
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| http://dx.doi.org/10.1007/BF00690365 | DOI Listing |
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