AI Article Synopsis
- Grouper iridovirus, a harmful pathogen affecting fish, can have its replication inhibited by quercetin, a natural compound from Illicium verum.
- Quercetin shows potential as an antiviral agent not only in lab conditions but also in live fish by enhancing the expression of key immune system genes related to type I interferon and TLR9.
- This research highlights quercetin's ability to indirectly combat grouper iridovirus, suggesting it could be a promising solution in aquaculture for preventing infections.
Article Abstract
Grouper iridovirus is a devastating pathogen that belongs to the genus Ranavirus. Based on the previous results that natural ingredient quercetin isolated from Illicium verum Hook. f. could effectively inhibit Singapore grouper iridovirus (SGIV) replication, suggesting that quercetin could serve as potential antiviral agent against grouper iridovirus. To know about whether quercetin has indirect antiviral activity against SGIV, this study made the investigation in vitro and in vivo, and the potential mechanism was also explored. Pretreating the cells with quercetin (12.5 μg/mL) significantly inhibited the replication of SGIV, similar results were also confirmed in vivo. Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9. It suggested that quercetin exerted the indirect antiviral activity against SGIV infection through promoting the recognition of SGIV and activating the IFN pathway to establish the antiviral status of host cell. Taken together, our results shedded light on the indirect antiviral function of natural ingredient quercetin, and clearly demonstrated that natural ingredient quercetin will be an excellent potential agent against SGIV infection in grouper aquaculture.
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| http://dx.doi.org/10.1016/j.fsi.2022.04.013 | DOI Listing |
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