AI Article Synopsis
- The study investigates the relationship between T cell responses and the severity of COVID-19 symptoms, alongside humoral immune responses.
- Increased levels of IgG antibodies were linked to more severe symptoms, but T cell responses didn't show significant variation across different symptom severities, except for specific symptoms like loss of smell/taste and cough.
- The results indicate that robust T cell responses may play a crucial role in reducing the severity of COVID-19 symptoms by aiding rapid virus clearance.
Article Abstract
Objectives: Besides SARS-CoV-2-directed humoral immune responses, T cell responses are indispensable for effective antiviral immunity. Recent data have shown a correlation between COVID-19 symptoms and humoral immune response, but so far, little is known about the association of SARS-CoV-2-directed T cell responses and disease severity. Herein, we evaluated the prevalence of different clinical COVID-19 symptoms in relation to SARS-CoV-2-directed humoral and cellular immune responses.
Methods: The severity of eight different symptoms during acute infection were assessed using questionnaires from 193 convalescent individuals and were evaluated in relation to SARS-CoV-2 antibody levels and intensity of SARS-CoV-2-specific T cell responses 2-8 weeks after positive polymerase chain reaction.
Results: Although increased IgG serum levels could be associated with severity of most symptoms, no difference in T cell response intensity between different symptom severities was observed for the majority of COVID-19 symptoms. However, when analyzing loss of smell or taste and cough, awareness of more severe symptoms was associated with reduced T cell response intensities.
Conclusions: These data suggest that rapid virus clearance mediated by SARS-CoV-2-specific T cells prevents severe symptoms of COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007751 | PMC |
| http://dx.doi.org/10.1016/j.ijid.2022.04.019 | DOI Listing |
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Article Synopsis
- The study investigates the relationship between T cell responses and the severity of COVID-19 symptoms, alongside humoral immune responses.
- Increased levels of IgG antibodies were linked to more severe symptoms, but T cell responses didn't show significant variation across different symptom severities, except for specific symptoms like loss of smell/taste and cough.
- The results indicate that robust T cell responses may play a crucial role in reducing the severity of COVID-19 symptoms by aiding rapid virus clearance.
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