AI Article Synopsis
- Patients with dementia have a higher risk of epilepsy, and this study aimed to assess if late-onset epilepsy (LOE) increases the risk of developing dementia.
- The meta-analysis reviewed seven cohort studies involving 873,438 adults, finding that 1.8% had LOE and that LOE was linked to a 2.39 times greater risk of dementia over an average follow-up of 8.7 years.
- The association was stronger among patients from hospitals compared to those from the community, and LOE was also associated with an increased risk of Alzheimer's and vascular dementia.
Article Abstract
Background: Patients with dementia have higher risk of epilepsy. However, it remains not comprehensively evaluated if late-onset epilepsy (LOE) is associated with higher risk of dementia. We, therefore, performed a meta-analysis to systematically evaluate the association.
Methods: Relevant cohort studies were identified by search of electronic databases including PubMed, Embase, and Web of Science. A randomized-effect model incorporating the possible between-study heterogeneity was used to pool the results.
Results: Overall, seven cohort studies including 873,438 adults were included, and 16,036 (1.8%) of them had LOE. With a mean follow-up duration of 8.7 years, 33,727 of them were diagnosed as dementia. Pooled results showed that LOE was associated with a higher risk of dementia (risk ratio [RR] 2.39, 95% confidence interval [CI] 2.04-2.81, p < 0.001, I = 67%). Results of subgroup analysis showed that the association between LOE and the risk of dementia was stronger in hospital-derived participants (RR 4.23, 95% CI 2.67-6.70, p < 0.001) than that in community-derived population (RR 2.25, 95% CI 1.93-2.63, p < 0.001; p for subgroup difference = 0.01). Pooled results of three studies showed that LOE was associated with a higher risk of Alzheimer's disease (RR 2.35, 95% CI 1.08-5.08, p = 0.03, I = 85%). One study suggested a significant association between LOE and risk of vascular dementia (RR 2.0, 95% CI 1.77-2.26, p < 0.001).
Conclusions: Evidence from cohort studies suggests that LOE may be a risk factor of dementia.
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| http://dx.doi.org/10.1007/s40520-022-02118-8 | DOI Listing |
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