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The genus Matsumuraja Schumacher, 1921 is an eastern Asiatic genus and was reviewed in China. After this research, M. polydactylota Qiao & Zhang syn.
View Article and Find Full Text PDFEndoscopic papillectomy versus surgical ampullectomy for adenomas and early cancers of the papilla: a retrospective Pancreas2000/European Pancreatic Club analysis.
Gut
December 2024
Department of Digestive and HBP Surgery, Groupe Hospitalier Pitié-Salpêtrière, Médecine Sorbonne Université APHP, Paris, France.
Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA.
Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and more), patients with hereditary syndromes and those undergoing pancreatoduodenectomy were excluded.
Exploring the impact of mitochondrial-targeting anthelmintic agents with GLUT1 inhibitor BAY-876 on breast cancer cell metabolism.
BMC Cancer
November 2024
Integrated Biosciences Graduate Program, University of Minnesota, 1035 Kirby Drive, Duluth, MN, 55812, USA.
Background: Cancer cells alter their metabolic phenotypes with nutritional change. Single agent approaches targeting mitochondrial metabolism in cancer have failed due to either dose limiting off target toxicities, or lack of significant efficacy in vivo. To mitigate these clinical challenges, we investigated the potential utility of repurposing FDA approved mitochondrial targeting anthelmintic agents, niclosamide, IMD-0354 and pyrvinium pamoate, to be combined with GLUT1 inhibitor BAY-876 to enhance the inhibitory capacity of the major metabolic phenotypes exhibited by tumors.
View Article and Find Full Text PDFIntroduction: Validity is frequently conceptualized in health professions education (HPE) assessment as an argument that supports the interpretation and uses of data. However, previous work has shown that many validity scholars believe argument and argumentation are relatively lacking in HPE. To better understand HPE's discourse around argument and argumentation with regard to assessment validity, the authors explored the discourses present in published HPE manuscripts.
View Article and Find Full Text PDFNerve injury converts Schwann cells in a long-term repair-like state in human neuroma tissue.
Exp Neurol
December 2024
Institute of Neurobiochemistry, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address:
Article Synopsis
- Peripheral nerve injuries can lead to the formation of neuromas, which are abnormal growths at the injury site that can stop nerves from healing properly.
- Researchers studied human neuroma tissue and compared it to healthy nerves from the same person to understand what happens at the injury site over time (1-13 months after injury).
- They found that even though the nerve repair cells called Schwann cells were present, they were in a "repair mode" and different from healthy cells, with signs of inflammation and reduced ability to form myelin, which is important for nerve function.
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