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A Rare Case of Pellagra in a Chronic Alcoholic.
Cureus
October 2023
Internal Medicine, Michigan State University at Hurley Medical Center, Flint, USA.
Article Synopsis
- - This report details a rare case of pellagra in a 60-year-old man with a history of chronic alcoholism, showcasing symptoms like a rash and diarrhea.
- - Laboratory tests showed significant niacin deficiencies, confirming the diagnosis, and initiating niacin supplements and dietary changes improved the patient's condition.
- - The case highlights the importance of recognizing the classic symptoms of pellagra—rash, diarrhea, and malnutrition—especially in individuals with alcohol use disorder for better health outcomes.
NAD, Axonal Maintenance, and Neurological Disease.
Antioxid Redox Signal
December 2023
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
The remarkable geometry of the axon exposes it to unique challenges for survival and maintenance. Axonal degeneration is a feature of peripheral neuropathies, glaucoma, and traumatic brain injury, and an early event in neurodegenerative diseases. Since the discovery of Wallerian degeneration (WD), a molecular program that hijacks nicotinamide adenine dinucleotide (NAD) metabolism for axonal self-destruction, the complex roles of NAD in axonal viability and disease have become research priority.
View Article and Find Full Text PDFProtective effect of BB536 against nausea caused by pirfenidone in a mouse model of pellagra.
Biosci Microbiota Food Health
March 2023
Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.
Pellagra is caused by abnormal intake and/or use of nicotinic acid and is known in part to be induced by the use of medications such as isoniazid or pirfenidone. We previously investigated atypical phenotypes of pellagra, such as nausea, using a mouse model of pellagra and found that gut microbiota play an important role in the development of these phenotypes. Here, we investigated the effect of BB536 on pellagra-related nausea caused by pirfenidone in our mouse model.
View Article and Find Full Text PDFScurvy: Rare Orthopaedic Complications Associated with Multinutritional Deficiencies.
Eur J Case Rep Intern Med
November 2022
The Royal Darwin Hospital, Tiwi, Northern Territory, Australia.
Unlabelled: Suboptimal nutrition can lead to deficiencies in micronutrients such as ascorbic acid (vitamin C), which can present with catastrophic neurological sequelae. Deficiencies of vitamin C, vitamin B3 (niacin) and zinc levels contribute to reduced bone density. Vitamin C associated vertebral fractures, although rare in adults, are still treatable if diagnosed early with a thorough clinical and nutritional history, and early supplementation.
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