AI Article Synopsis
- The Ppargc1a gene produces various PGC-1α isoforms that help control energy production in mitochondria and adapt cellular processes.
- Activating certain PGC-1α isoforms in mice can protect against different diseases.
- The overview highlights how factors like gene expression, splicing, translation, protein stability, and activity contribute to the diverse functions of Ppargc1a.
Article Abstract
The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes several PGC-1α isoforms that regulate mitochondrial bioenergetics and cellular adaptive processes. Expressing specific PGC-1α isoforms in mice can confer protection in different disease models. This SnapShot summarizes how regulation of Ppargc1a transcription, splicing, translation, protein stability, and activity underlies its multifaceted functions. To view this SnapShot, open or download the PDF.
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| http://dx.doi.org/10.1016/j.cell.2022.03.027 | DOI Listing |
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