Retraction: Self-association of L-periaxin occurs its acidic domain and NLS2/NLS3, and affects its trafficking in RSC96 cells.

RSC Adv

Institute of Biotechnology, Key Laboratory of Chemical Biology, Molecular Engineering of Ministry of Education, Shanxi University Taiyuan 030006 P. R. China +86-351-7018268.

Published: April 2021

AI Article Synopsis

  • The article with DOI: 10.1039/C7RA06853K has been officially retracted.
  • This means that the findings and conclusions presented in the article are no longer considered valid or trustworthy.
  • Readers and researchers should disregard the information from this article moving forward.

Article Abstract

[This retracts the article DOI: 10.1039/C7RA06853K.].

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698224PMC
http://dx.doi.org/10.1039/d1ra90105bDOI Listing

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Article Synopsis
  • The article with DOI: 10.1039/C7RA06853K has been officially retracted.
  • This means that the findings and conclusions presented in the article are no longer considered valid or trustworthy.
  • Readers and researchers should disregard the information from this article moving forward.
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The role of ERp44 in maturation of serotonin transporter protein.

J Biol Chem

May 2012

Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205. Electronic address:

In heterologous and endogenous expression systems, we studied the role of ERp44 and its complex partner endoplasmic reticulum (ER) oxidase 1-α (Ero1-Lα) in mechanisms regulating disulfide bond formation for serotonin transporter (SERT), an oligomeric glycoprotein. ERp44 is an ER lumenal chaperone protein that favors the maturation of disulfide-linked oligomeric proteins. ERp44 plays a critical role in the release of proteins from the ER via binding to Ero1-Lα.

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Serotonin [5-hydroxytryptamine (5HT)] is a vasoconstrictor that also acts as a developmental signal early in embryogenesis. The 5HT transporter (SERT) on the membranes of the placental trophoblast cells controls 5HT levels in the maternal bloodstream to maintain stable transplacental blood flow and simultaneously provide 5HT to the embryo. The 5HT uptake rate of placental SERT is important for both the mother and the developing embryo.

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