Radical and transition metal-catalyzed cascade cyclization strategies were investigated with respect to the synthesis of the tetracyclic core of the augustamine-type Amaryllidaceae alkaloids. These studies resulted in the synthesis of noraugustamine and the development of an oxidative Heck/aza-Wacker cascade forming two rings, a C-N bond, and an all-carbon quaternary center in a single step.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.2c00948 | DOI Listing |
Publication Analysis
Top Keywords
synthesis noraugustamine
8
noraugustamine development
8
development oxidative
8
oxidative heck/aza-wacker
8
heck/aza-wacker cascade
8
cascade cyclization
8
cyclization radical
4
radical transition
4
transition metal-catalyzed
4
metal-catalyzed cascade
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!