The heavy and rigid appearance of conventional burnt building tiles is not suitable for a global sustainable development strategy. Flexible facing tiles with lightweight and environmental materials are highly desirable for the construction industry today. In this work, water-based polymer emulsion-assisted flexible building tiles were prepared. Based on the method of achieving post crosslinking and improving adhesion with inorganic matrix-based materials, WPAs modified with GMA and KH570 display good chemical resistance and low solvent absorption (0.132 in water and 0.289 in ethanol respectively). The optimum mechanical performance of flexible building materials prepared with WPAs can strain 1.406% and stress 1.8658 MPa. The TGA, XRD, SEM and AFM results further indicate the excellent thermal stability and compatibility of flexible building tiles. Hence, flexible building tiles prepared with WPAs can be promising building materials for construction.
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http://dx.doi.org/10.1039/d2ra00045h | DOI Listing |
Environ Toxicol Chem
January 2025
ToxStrategies, LLC, Katy, TX, USA.
A key component of ecological risk assessments is to develop evidence-based benchmarks to assess potential hazards to various receptors. To ensure that toxicity value development is performed using the best available science, the reliability (or inherent scientific quality) of these studies must be considered. The degree of reliability can be evaluated via critical appraisal tools (CATs), though application of such methods assessing ecotoxicological literature for toxicity value development is not well established compared to human health assessments.
View Article and Find Full Text PDFJ Am Med Inform Assoc
January 2025
Department of Computer Science, Duke University, Durham, NC 27708, United States.
Objective: Prediction of mortality in intensive care unit (ICU) patients typically relies on black box models (that are unacceptable for use in hospitals) or hand-tuned interpretable models (that might lead to the loss in performance). We aim to bridge the gap between these 2 categories by building on modern interpretable machine learning (ML) techniques to design interpretable mortality risk scores that are as accurate as black boxes.
Material And Methods: We developed a new algorithm, GroupFasterRisk, which has several important benefits: it uses both hard and soft direct sparsity regularization, it incorporates group sparsity to allow more cohesive models, it allows for monotonicity constraint to include domain knowledge, and it produces many equally good models, which allows domain experts to choose among them.
Chem Asian J
January 2025
Indian Institute of Science Education and Research Bhopa;, Chemistry, IISER Bhopal, Chemistry, #229,, Academic Building #2, Bhopal bypass road, Bhauri, 462066, Bhopal, INDIA.
Polymerases erroneously incorporate Guanine-Thymine (dG•dT) mismatches in genomic DNA that further evades repair by transient sampling of tautomeric/ionic states compromising fidelity of repairing dG•dT mismatches. In conjunction, significant frequency of ribose (mis)incorporation in duplex DNA permits for misincorporated-mismatch in the genome. Ribose incorporated G(rG) mismatched with T(rG•dT) is the most stable across all misincorporated-mismatch calling into question the conformational consequences of the ribose sugar in addition to the mismatch.
View Article and Find Full Text PDFAtten Percept Psychophys
January 2025
Department of Psychology, The Ohio State University, 225 Psychology Building, 1835 Neil Ave, Columbus, OH, 43210, USA.
Humans can learn to attentionally suppress salient, irrelevant information when it consistently appears at a predictable location. While this ability confers behavioral benefits by reducing distraction, the full scope of its utility is unknown. As people locomote and/or shift between task contexts, known-to-be-irrelevant locations may change from moment to moment.
View Article and Find Full Text PDFNat Metab
January 2025
Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province, Taiyuan, China.
Skeletal muscle is a critical organ in maintaining homoeostasis against metabolic stress, and histone post-translational modifications are pivotal in those processes. However, the intricate nature of histone methylation in skeletal muscle and its impact on metabolic homoeostasis have yet to be elucidated. Here, we report that mitochondria-rich slow-twitch myofibers are characterized by significantly higher levels of H3K36me2 along with repressed expression of Kdm2a, an enzyme that specifically catalyses H3K36me2 demethylation.
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