A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by -weighted MR imaging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981495 | PMC |
| http://dx.doi.org/10.1039/d2ra00614f | DOI Listing |
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