An efficient and powerful copper-assisted method for the effective conversion of a broad range of hydroxypyridines and sodium sulfinates into their corresponding pyridinyl tosylates was developed. Key features of this base- and ligand-free protocol include using the cheap and readily available CuBr as a medium and the use of sodium sulfinates as formal sulfonylation reagents. A variety of functional pyridinyl tosylates could be formed with good yields, which can easily be converted into C-C and C-N bond-containing compounds.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979058 | PMC |
| http://dx.doi.org/10.1039/d1ra08568a | DOI Listing |
Publication Analysis
Top Keywords
sodium sulfinates
12
hydroxypyridines sodium
8
pyridinyl tosylates
8
copper-assisted preparation
4
preparation pyridinyl
4
pyridinyl sulfonate
4
sulfonate esters
4
esters hydroxypyridines
4
sulfinates efficient
4
efficient powerful
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!