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Effect of the enantiomeric structure of hydrophobic polymers on the encapsulation properties of a second near infrared (NIR-II) fluorescent dye for deep imaging. | LitMetric

AI Article Synopsis

  • Over-thousand-nanometer (OTN) near-infrared (NIR) fluorophores, like IR-1061, are valuable for deep biological imaging due to their ability to penetrate tissues with minimal absorption and scattering.
  • The IR-1061 dye's effectiveness relies on being encapsulated in hydrophobic polymer micelles, where the compatibility between the dye and polymer core plays a crucial role in its performance for bioimaging applications.
  • This study found that the dye had a greater affinity for certain chiral poly(lactic acid) copolymers (l- and d-lactic acid) compared to others, highlighting the importance of selecting appropriate hydrophobic polymers for creating stable and effective OTN-NIR fluorescent

Article Abstract

Over-thousand-nanometer (OTN) near-infrared (NIR) fluorophores are useful for biological deep imaging because of the reduced absorption and scattering of OTN-NIR light in biological tissues. IR-1061, an OTN-NIR fluorescent dye, has a hydrophobic and cationic backbone in its molecular structure, and a non-polar counter ion, BF . Because of its hydrophobicity, IR-1061 needs to be encapsulated in a hydrophobic microenvironment, such as a hydrophobic core of polymer micelles, shielded with a hydrophilic shell for bioimaging applications. Previous studies have shown that the affinity of dyes with hydrophobic core polymers is dependent on the polarity of the core polymer, and that this characteristic is important for designing dye-encapsulated micelles to be used in bioimaging. In this study, the dye-polymer affinity was investigated using hydrophobic polymer films with different chiral structures of poly(lactic acid). IR-1061 showed higher affinity for l- and d-lactic acid copolymers (, poly(dl-lactic acid) (PDLLA)) than to poly(l-lactic acid) (PLLA), as IR-1061 shows less dimerization in PDLLA than in PLLA. In contrast, the stability of IR-1061 in PDLLA was less than that in PLLA due to the influence of hydroxyl groups. Choosing hydrophobic core polymers for their robustness and dye affinity is an effective strategy to prepare OTN-NIR fluorescent probes for deep imaging.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979197PMC
http://dx.doi.org/10.1039/d1ra08330aDOI Listing

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