A concise and efficient procedure for the total synthesis of natural stilbene dimer (±)--viniferin was accomplished with high overall yield. Demethylation of the key intermediate methyl 3-arylbenzofuran-4-carboxylate was achieved successfully through bromination followed by BBr-or BCl/TBAI-mediated ether cleavage reaction. Pd/C and bromobenzene-catalyzed MOM ether cleavage was successfully carried out to aquire (±)--viniferin.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992221 | PMC |
| http://dx.doi.org/10.1039/d2ra01385a | DOI Listing |
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