A facile CuBr induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-]isoquinolines and benzimidazo[2,1-]isoquinolin-6(5)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance.
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| http://dx.doi.org/10.1039/d1ra06981k | DOI Listing |
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