AI Article Synopsis
- A new method for the asymmetric hydrogenation of allylamines uses CO2 to prevent side reactions.
- Various factors like pressure, time, solvent, and base additives were analyzed to enhance enantioselectivity and conversion.
- The method achieved total conversion of 2-arylprop-2-en-1-amine with an enantiomeric excess of up to 82%, showing that the right choice of base improves selectivity in the reaction.
Article Abstract
A new methodology for the asymmetric hydrogenation of allylamines takes advantage of a reversible reaction between amines and carbon dioxide (CO) to suppress unwanted side reactions. The effects of various parameters (pressure, time, solvent, and base additives) on the enantioselectivity and conversion of the reaction were studied. The homogeneously-catalyzed asymmetric hydrogenation of 2-arylprop-2-en-1-amine resulted in complete conversion and up to 82% enantiomeric excess (ee). Added base, if chosen carefully, improves the enantioselectivity and chemoselectivity of the overall reaction.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981594 | PMC |
| http://dx.doi.org/10.1039/d2ra00263a | DOI Listing |
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