C-diterpenoid alkaloids in tribe (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities.

This review systematically summarizes the C-diterpenoid alkaloid (DA) compositions isolated from the genera and in the tribe (Ranunculaceae). A total of 117 distinct C-DA components have been reported, including 58 lappaconitine-type DAs, 54 ranaconitine-type DAs, and five rearranged-type DAs. These components mainly originated from plants from the subgenus in the genus or less frequently from plants within the genus . Natural C-DAs have exhibited a wide range of bioactivities, including analgesic, antiarrhythmic, anti-inflammatory, anti-tumor, and insecticidal activities, which are closely related to their chemical structures. The high chemical and biological diversities among the reported C-DA constituents in plants indicated their potential as a vast resource for drug discovery. Additionally, the plant C-DAs exhibited chemotaxonomic values and showed a high regularity of distribution at different taxonomic levels; therefore, the plant C-DAs can serve as good chemical molecular markers in the taxonomic treatment of plants within this tribe, especially in the infrageneric division.