Laser synthesis: a solvent-free approach for the preparation of phenylthiazolo[5,4-]pyridine derivatives.

RSC Adv

Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR, CNRS 7311 BP 6759, rue de Chartres 45067 Orléans cedex 2 France

Published: January 2021

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Article Abstract

We describe here a rapid and straightforward solvent-free method to access phenylthiazolo[5,4-]pyridines using a Nd-YAG laser NANO-NY81-10 ( = 355 nm, 10 Hz pulse frequency; 8 ns pulse duration). This newly presented method successfully brings several improvements to the laser assisted synthesis of ,-heterocycles. We are able to provide a solvent-, metal- and base-free method with good yield and a substantial reduction in reaction time.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694535PMC
http://dx.doi.org/10.1039/d0ra10094cDOI Listing

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