The suppression effect of hydrophobic nano SiO of different concentrations as flow-enhancing additives synergizing with CaCO to inhibit gas explosions was systematically studied in a self-built LabVIEW-based explosion test platform. The results showed that the addition of hydrophobic powder can reduce the angle of rest and enhance the flowability of mixed powders, and improve the powder diffusion effect and storability. Meanwhile, changing the proportion and concentration of the mixed powders had a significant impact on the combustion reaction, so that the flame propagation velocity and explosion overpressure decreased significantly. However, excessive powder concentration will promote the combustion reaction at the initial stage of the explosion, and the synergistic inhibition effect of the two powders on explosions is better than that of a single powder. Based on the above results, the optimum suppression concentration and proportion were determined, the mechanism of suppressing gas explosion by a powder was analyzed, and the coupling relationship between flame velocity and pressure was summarized.
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http://dx.doi.org/10.1039/d0ra09223a | DOI Listing |
Pharmaceutics
January 2025
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.
Background/objectives: This study investigates for the first time the use of the prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles to deliver properly an active pharmaceutical ingredient. Curcumin (CCM), a hydrophobic compound classified under BCS (Biopharmaceutics Classification System) class IV, was selected as the model drug.
Methods: Key process parameters, including polymer concentration, solvent type, nozzle size, and surfactant levels, were optimized to obtain stable particles with a narrow size distribution determined by DLS analysis.
Pharmaceutics
January 2025
Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.
: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. This study explores a co-precipitation method to prepare co-formulated crystals of griseofulvin (GF) and dexamethasone (DXM), utilizing nanostructured, functionalized polylactic glycolic acid (PLGA) as a solubility enhancer. : An antisolvent precipitation technique was employed to incorporate PLGA at a 3% concentration into the co-formulated GF and DXM, referred to as DXM-GF-PLGA.
View Article and Find Full Text PDFBioorg Chem
January 2025
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia. Electronic address:
Multi-drug-resistant (MDR) pathogens represent a critical global health threat, necessitating the development of novel antimicrobial agents with broad-spectrum activity and minimal toxicity. This study investigates the antimicrobial and anti-biofilm properties of 4-Allyl-2-methoxyphenol (eugenol, EU) and (E)-3-Phenylprop-2-enal (cinnamaldehyde, CN) against 19 clinically significant pathogens through a combination of in-vitro assays and in-silico analyses. EU displayed remarkable activity, particularly against Aspergillus niger (20.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Bacterial plant diseases, worsened by biofilm-mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three-component supramolecular nano-biscuits (NI6R@CB[7]@β-CD) are successfully engineered via ordered self-assembly between two macrocycles [cucurbit[7]uril (CB[7]), β-cyclodextrin (β-CD)] and (R)-2-naphthol-based bis-imidazolium bromide salt (NI6R).
View Article and Find Full Text PDFLangmuir
January 2025
CAS Key Laboratory of Colloid, Interface, and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Molds are persistent and harmful but receive far less research attention compared with pathogenic bacteria. With the increase in microbial resistance to single-chain surfactant antimicrobial agents, it is crucial to investigate how surfactant structures affect the antimicrobial activity of surfactants. Here, we have studied the antimold efficacy of a series of oligomeric cationic quaternary ammonium surfactants at varying oligomerization levels with or without dynamic covalent imine bonds.
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