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Background/objectives: This study investigates for the first time the use of the prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles to deliver properly an active pharmaceutical ingredient. Curcumin (CCM), a hydrophobic compound classified under BCS (Biopharmaceutics Classification System) class IV, was selected as the model drug.

Methods: Key process parameters, including polymer concentration, solvent type, nozzle size, and surfactant levels, were optimized to obtain stable particles with a narrow size distribution determined by DLS analysis.

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: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. This study explores a co-precipitation method to prepare co-formulated crystals of griseofulvin (GF) and dexamethasone (DXM), utilizing nanostructured, functionalized polylactic glycolic acid (PLGA) as a solubility enhancer. : An antisolvent precipitation technique was employed to incorporate PLGA at a 3% concentration into the co-formulated GF and DXM, referred to as DXM-GF-PLGA.

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Repurposing eugenol and cinnamaldehyde as potent antimicrobial agents: A comprehensive in-vitro and in-silico study.

Bioorg Chem

January 2025

Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia. Electronic address:

Multi-drug-resistant (MDR) pathogens represent a critical global health threat, necessitating the development of novel antimicrobial agents with broad-spectrum activity and minimal toxicity. This study investigates the antimicrobial and anti-biofilm properties of 4-Allyl-2-methoxyphenol (eugenol, EU) and (E)-3-Phenylprop-2-enal (cinnamaldehyde, CN) against 19 clinically significant pathogens through a combination of in-vitro assays and in-silico analyses. EU displayed remarkable activity, particularly against Aspergillus niger (20.

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Bacterial plant diseases, worsened by biofilm-mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three-component supramolecular nano-biscuits (NI6R@CB[7]@β-CD) are successfully engineered via ordered self-assembly between two macrocycles [cucurbit[7]uril (CB[7]), β-cyclodextrin (β-CD)] and (R)-2-naphthol-based bis-imidazolium bromide salt (NI6R).

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Anti-Mold Activities of Cationic Oligomeric Surfactants.

Langmuir

January 2025

CAS Key Laboratory of Colloid, Interface, and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Molds are persistent and harmful but receive far less research attention compared with pathogenic bacteria. With the increase in microbial resistance to single-chain surfactant antimicrobial agents, it is crucial to investigate how surfactant structures affect the antimicrobial activity of surfactants. Here, we have studied the antimold efficacy of a series of oligomeric cationic quaternary ammonium surfactants at varying oligomerization levels with or without dynamic covalent imine bonds.

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