A series of 2-ethoxycarbonylthieno[2,3-]quinolines were synthesized in the bio-derived "green" solvent γ-valerolactone (GVL) and evaluated for their inhibitory activities against PTP1B, the representative compound 6a displayed an IC value of 8.04 ± 0.71 μM with 4.34-fold preference over TCPTP. These results provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694002 | PMC |
| http://dx.doi.org/10.1039/d0ra09247a | DOI Listing |
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