Theoretical calculation of the reactivity of α-imino thioesters indicates that they are very reactive substrates for Umpolung -alkylation. In fact, treatment of α-aldimino thioesters with dialkylzinc reagents in the presence of aldehydes or imines gives three-component coupling products in good yields.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697212 | PMC |
| http://dx.doi.org/10.1039/d1ra02000e | DOI Listing |
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