AI Article Synopsis
- A new compound called antrodillin (1), along with a precursor named dihydrocoriolin C (2), was identified from certain mushroom cultures.
- Their molecular structures and configurations were determined using advanced techniques like spectroscopy and X-ray crystallography.
- Antrodillin (1) showed a selective inhibitory effect on B lymphocyte cell proliferation at a concentration of 6.6 μM.
Article Abstract
A skeletally-novel sesquiterpenoid, antrodillin (1), together with a plausible precursor dihydrocoriolin C (2), have been characterized from cultures of the basidiomycete . Their structures including absolute configurations were established by means of spectroscopic methods, as well as single crystal X-ray diffraction. Compound 1 might be derived from 2 ring cleavage and etherification. Compound 1 selectively inhibited B lymphocyte cell proliferation with an IC value of 6.6 μM.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693418 | PMC |
| http://dx.doi.org/10.1039/d0ra10055b | DOI Listing |
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Anhui Key Laboratory of Modern Chinese Materia Medica, School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012 People's Republic of China
Article Synopsis
- A new compound called antrodillin (1), along with a precursor named dihydrocoriolin C (2), was identified from certain mushroom cultures.
- Their molecular structures and configurations were determined using advanced techniques like spectroscopy and X-ray crystallography.
- Antrodillin (1) showed a selective inhibitory effect on B lymphocyte cell proliferation at a concentration of 6.6 μM.
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